Teaching the Science of Life: A Multidisciplinary Educational Approach to Reproductive Technology Debates Through the Lens of Developmental Biology.

In vitro fertilization, cryopreservation and pre-implantation genetic testing are transformative reproductive technologies offering hope for individuals facing fertility challenges. Scientifically, understanding the science of developmental biology is essential for comprehending the mechanisms and implications of these technologies. In embryological sciences, biological perspectives identify life as a series of developmental stages ranging from conception to viability, each potentially representing a different 'beginning' of life.

The prognostic relevance of donor-specific antibodies in facial transplantation - A retrospective cohort study.

Background: Little is known about the prognostic relevance of donor-specific antibodies (DSAs) and C4d tissue deposition for acute and chronic rejection in facial vascularized composite allotransplantation.

Methods: We conducted a retrospective analysis of nine face transplant patients. Outcome measures, such as DSA positivity, were determined by the local tissue typing laboratory, whereas C4d deposition was assessed by immunostaining.

The moderating effect of the psychosocial working conditions (effort/reward/overcommitment) on the association between noise annoyance and cognitive performance among adolescents.

Objectives: The primary objective of the current study was to evaluate the correlation between noise-induced annoyance and the cognitive performance within the Lebanese adolescent population and the moderating effect of psychosocial work aspects-namely effort, reward, and overcommitment- in this association.

Methods: An anonymous online survey was conducted in Lebanon between April and May 2023, using a snowball sampling technique and distributed across various social media platforms, to gather data from Lebanese adolescents. The sample was composed of 1269 adolescents.

Causally-informative analyses of the effect of job displacement on all-cause and specific-cause mortality from the 1990s Finnish recession until 2020: A population registry study of private sector employees.

Background: Job loss is related to morbidity and mortality, but generation of causal evidence is challenging due to confounding factors. Finland suffered a severe economic recession in the early 1990s with unemployment reaching almost 25%, with many job losses due to mass layoff or company closure. Such job displacements are assumed to be exogenous to the individual and create a natural experiment for causal inference.

Psychometric properties of the Arabic versions of the perceived social competence scale and the prosociality scale.

Background: Prosocial behaviors refer to a variety of voluntary actions intended to benefit others and the society. They have consistently proven their capacity to promote individuals' well-being and personal development. Nevertheless, these constructs remain largely underexplored in the Arab world.

Search for New Resonances Decaying to Pairs of Merged Diphotons in Proton-Proton Collisions at sqrt[s]=13 TeV.

A search is presented for an extended Higgs sector with two new particles, X and ϕ, in the process X→ϕϕ→(γγ)(γγ). Novel neural networks classify events with diphotons that are merged and determine the diphoton masses. The search uses LHC proton-proton collision data at sqrt[s]=13  TeV collected with the CMS detector, corresponding to an integrated luminosity of 138  fb^{-1}.

Mathematics Self-Efficacy of Brazilian High School Students: A Mixed-Methods Approach Study.

This study examines the mathematics self-efficacy of 833 high school students from four Brazilian public schools. Using an exploratory cross-sectional design with a mixed-methods approach, students completed online instruments including a sociodemographic questionnaire, scales measuring various self-efficacy domains (mathematics, self-regulated learning, social and emotional) and open-ended questions about their perceived attributes in learning mathematics. Multiple regression analysis revealed that student characteristics and self-efficacy domains collectively explained 47.

Priority Should be Given to Centers that Split En Bloc Pediatric Kidneys to Maximize Transplantation: A Single Center Experience.

The foundation for OPTN policy 8.5.B that allows for en bloc kidney utilization from pediatric donors under <18 kg is unclear.

Effect of postpartum oral furosemide use on postpartum readmissions and blood pressure trends.

Background: Oral furosemide postpartum improves the time to hypertension resolution in randomized control trials. Further investigation is needed to determine the impact of furosemide in routine clinical practice.

Objective: Real world study to assess impact of furosemide on rates of postpartum hypertension and readmissions for patients with hypertensive disorders of pregnancy.

B-cell infiltration distinguishes mucosal from skin patterns of rejection in facial vascularized composite allografts.

Rejection monitoring in facial vascularized composite allotransplantation traditionally focuses on skin biopsies. However, mucosal rejection frequently presents with more pronounced signs of immune activity. To explore mechanistic differences between skin and mucosal rejection, rejection and nonrejection biopsies from allograft skin and oral mucosa of 9 facial vascularized composite allotransplantation recipients were retrospectively analyzed using histology, multiplex immunostaining, and gene expression profiling, with peripheral blood mononuclear cells quantified via mass cytometry.

Neonatal cost savings in hypertensive disorders of pregnancy: Economic evaluation of the sFlt-1/PlGF test with real world implementation of biomarkers.

Background: Preeclampsia is a key cause of prematurity in the U.S. and incurs significant healthcare costs.

Impacts of Ethical Dilemmas and Moral Distress in Pediatric Hematology Oncology Nurses.

Purpose: To assess the level of moral distress (MD) and perceptions of ethical climate among pediatric hematology/oncology (PHO) nurses and to identify bioethics topics where increased education was desired.

Methods: In this cross-sectional study, we administered the 26-item Swedish Moral Distress Scale-Revised (sMDS-R), specifically revised and validated for pediatric oncology, in conjunction with the Clinical Ethics Needs Assessment Survey (CENAS). Electronic surveys were sent to inpatient and outpatient PHO nurses.

Unearthing Genetic Treasures: Exploring Lost Autochthonous Varieties in Lebanon.

Background/objectives: Lebanon, one of the oldest centers of grapevine ( L.) cultivation, is home to a rich diversity of local grape varieties. This biodiversity is linked to the country's unique topography and millennia of cultural history.

Curcumin Encapsulation in Aluminum Fumarate Metal-Organic Frameworks for Enhanced Stability and Antioxidant Activity.

Curcumin (Cur) is a great candidate for antioxidant applications; however, due to its low solubility and poor bioavailability, it remains only hardly employed as a therapeutic agent. Moreover, curcumin is very unstable and tends to degrade quickly. Metal-organic frameworks (MOFs) have gained great attention in the field of drug loading due to their diversity and tunability, so they are seen as great candidates for hosting curcumin.

Addressing Pre-exposure Prophylaxis Awareness and Knowledge Gaps Among Lebanese Medical Professionals: A Cross-Sectional Study.

Objective: In Lebanon, HIV prevalence among key populations such as men who have sex with men is high at 12%, warranting a need for targeted healthcare efforts. Pre-exposure prophylaxis (PrEP) is an effective prevention measure, yet global challenges persist, including limited awareness of PrEP among healthcare professionals. This study investigates PrEP awareness within the Lebanese medical community.

Acute lower limb ischemia revealing hypo granular acute promyelocytic leukemia.

Introduction: Acute promyelocytic leukemia (AML-M3), classified as acute Myeloid leukemia with PML RARA according to the 5th edition of the World Health Organization classification of haematolymphoid tumors 2022 [1], is marked by abnormal promyelocyte proliferation and is known for high risks of bleeding and thromboembolic complications. We present a case where lower limb ischemia revealed this leukemia in a child.

Case Report: An 11-year-old with minor ankle trauma developed severe lower limb ischemia, leading to the discovery of subtotal femoral artery thrombosis.

Multiple ovulation was positively associated with milk yield independently of circulating progesterone concentrations in multiparous high-producing Holstein cows submitted to Double-Ovsynch.

The present study aimed to determine the relationship between circulating progesterone (P4) concentrations and milk yield during the ovulatory follicular wave on the proportion of multiple ovulation (MOV) in multiparous high-producing Holstein cows (n = 1,345). The study used first-service multiparous cows submitted to a Double-Ovsynch program (GnRH; 7 d later, PGF; 3 d later, GnRH; 7 d later, GnRH [G1]; 7 d later, PGF [PG1]; 1 d later, PGF; ∼32 h later, GnRH [G2]; ∼16 h later, timed AI [TAI]). To assess ovulatory response and proportion of MOV, ovarian ultrasonography examinations were performed at G1 (n = 1,215) and G2 (n = 1,345) and from 40 to 48 h after each GnRH.

Strategies to increase circulating progesterone in late metestrus and early diestrus in recipient dairy heifers and cows: A focus on induction of accessory corpus luteum formation.

The capacity of recipients to support transferred embryos is a challenge for dairy cattle production systems. This review explores methods for increasing P4 to improve early pregnancy establishment in dairy cattle. A key aspect of P4 supplementation during the critical first weeks of pregnancy is its correlation with successful embryo elongation.

Drug-Coated Balloons in Percutaneous Coronary Intervention: Beyond Evidence.

Drug-coated balloons (DCBs) represent a promising alternative to drug-eluting stents (DESs) by adopting a "leave-nothing-behind" approach, avoiding the long-term implantation of metallic materials associated with vessel damage, stent thrombosis, and restenosis. Although DCBs have historically been indicated for patients with in-stent restenosis or de novo small-vessel disease, recent studies indicate the potential for broader applications in acute coronary syndromes (ACSs). Trials comparing DCB and DES treatments show that DCBs yield comparable long-term outcomes, with some studies suggesting reduced rates of secondary endpoints such as cardiac death and non-fatal myocardial infarction among ACS patients treated with DCBs.

Effect of gonadorelin dose and an additional gonadorelin treatment 2 days after the initiation of Resynch-25 on ovarian dynamics and fertility of lactating Holstein cows.

Our objective was to improve ovulatory response at the initiation of the Resynch-25 protocol by (1) increasing the dose of GnRH from 100 µg to 200 µg; and (2) giving a second GnRH treatment 56 h after the initiation of the protocol. We considered the experimental d 0 the day of the previous service. The experiment consisted of a 2 × 2 factorial design to compare the main effects of GnRH dose (100 vs.

Search for Soft Unclustered Energy Patterns in Proton-Proton Collisions at 13 TeV.

The first search for soft unclustered energy patterns (SUEPs) is performed using an integrated luminosity of 138  fb^{-1} of proton-proton collision data at sqrt[s]=13  TeV, collected in 2016-2018 by the CMS detector at the LHC. Such SUEPs are predicted by hidden valley models with a new, confining force with a large 't Hooft coupling. In events with boosted topologies, selected by high-threshold hadronic triggers, the multiplicity and sphericity of clustered tracks are used to reject the background from standard model quantum chromodynamics.

The Empty Office: protocol for sequential mixed-method study on the impact of telework activities on social relations and well-being.

Introduction: Teleworking is one of the most significant legacies of the pandemic. Great attention is now being paid to its effects on workers' health. One of the arguments that emerged on this issue is that 'working away from the office' affects the time we spend with significant others.