Publications by authors named "Jovan S Brockett"
Centrosomes rely upon proteins within the pericentriolar material to nucleate and organize microtubules. Several mRNAs also reside at centrosomes, although less is known about how and why they accumulate there. We previously showed that local () mRNA supports centrosome separation, microtubule organization, and viability in embryos.
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- Mutations in the SETD2 gene are common in renal cell carcinoma (RCC), and a specific single nucleotide polymorphism (SNP), E902Q, was found in some RCC patients as an inherited or tumor-related mutation.
- Researchers used CRISPR to create a similar mutation in the fruit fly gene Set2, discovering that it significantly lowered an important histone modification (H3K36me3) and led to problems with spindle formation during cell division.
- The findings suggest that the SETD2 E902Q SNP not only influences histone methylation and spindle integrity but could also have important implications for understanding and treating RCC clinically.
Formation of a zygote is coupled with extensive epigenetic reprogramming to enable appropriate inheritance of histone methylation and prevent developmental delays. In , this reprogramming is mediated by the H3K4me2 demethylase SPR-5 and the H3K9 methyltransferase, MET-2. In contrast, the H3K36 methyltransferase MES-4 maintains H3K36me2/3 at germline genes between generations to facilitate re-establishment of the germline.
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