Publications by Jovan Prerad

Publications by authors named "Jovan Prerad"

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A pathogenic mutation in the ALS/FTD gene VCP induces mitochondrial hypermetabolism by modulating the permeability transition pore.

Silke Vanderhaeghe Jovan Prerad Arun Kumar Tharkeshwar Elien Goethals Katlijn Vints

Acta Neuropathol Commun

October 2024

Article Synopsis

Valosin-containing protein (VCP) is linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), and this study investigates how a mutation in VCP affects mitochondrial function using CRISPR/Cas9 in neuroblastoma cells.
The mutated cells show enlarged mitochondria with a depolarized membrane potential, leading to increased respiration and heightened activity in the electron transport chain.
The findings suggest that VCP mutations may cause mitochondrial hypermetabolism through changes in the permeability transition pore (mPTP), impacting mitochondrial function and contributing to disease progression.

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Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer's disease.

Katrien Princen Tom Van Dooren Marit van Gorsel Nikolaos Louros Xiaojuan Yang Jovan Prerad

Science

May 2024

Abnormal calcium signaling is a central pathological component of Alzheimer's disease (AD). Here, we describe the identification of a class of compounds called ReS19-T, which are able to restore calcium homeostasis in cell-based models of tau pathology. Aberrant tau accumulation leads to uncontrolled activation of store-operated calcium channels (SOCCs) by remodeling septin filaments at the cell cortex.