Publications by authors named "Jourdan Anderson"
Article Synopsis
- Systemic lupus erythematosus (SLE) is an autoimmune disease linked to the immune system's dysregulation, particularly involving autoantibodies and molecular mimicry with pathogens like Epstein-Barr virus (EBV).
- The study found that mice expressing a hybrid molecule (mCD40-LMP1) showed heightened immune responses after exposure to EBV's EBNA-1, including increased cytokines and antibodies, leading to autoimmune-like features without overt disease.
- When these mice were also immunized with the lupus autoantigen Sm, they demonstrated significantly enhanced immune reactions to both Sm and EBNA-1, which could indicate a connection between EBV and autoimmunity in SLE
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