A New Mechanism for the Inhibition of SA106 Gr.B Carbon Steel Corrosion by Nitrite in Alkaline Water.

The purpose of this study was to investigate the composition of oxide films formed on SA106 Gr.B carbon steel in nitrite solutions at 35 °C for 1000 h. The product of the reduction of nitrite during the corrosion inhibition process was also examined.

Targeted combinational therapy inducing mitochondrial dysfunction.

We report on a mitochondria-specific combinational theranostic agent, 1. This system contains a chlorambucil prodrug and an aggregation induced emission dye. In addition, compound 1 bears both an intracellular thiol-triggered moiety and a mitochondria targeting unit (triphenylphosphonium).

Mitochondria-targeted aggregation induced emission theranostics: crucial importance of activation.

Tissue selective targeting and specific suborganellular localization combined with an efficient pathology associated enzymatic activation of drugs in drug delivery systems may exhibit a clear advantage over conventional cancer treatment. Here, a mitochondria targeted aggregation induced emission (AIE) fluorophore further conjugated with an NAD(P)H:quinone oxidoreductase-1 (NQO1) cleavable masking unit showed preferential uptake in cancer cells and was selectively activated, resulting in bright AIE fluorescence and apoptosis the caspase pathway, triggered by mitochondrial dysfunction. experimental data further support the conclusions from experiments, clearly showing the dependence of the therapy's success on both the suborganelle localization and specific activation.

Roles of chemical metrology in electronics industry and associated environment in Korea: a tutorial.

Chemical metrology is gaining importance in electronics industry that manufactures semiconductors, electronic displays, and microelectronics. Extensive and growing needs from this industry have raised the significance of accurate measurements of the amount of substances and material properties. For the first time, this paper presents information on how chemical metrology is being applied to meet a variety of needs in the aspects of quality control of electronics products and environmental regulations closely associated with electronics industry.

A Nile Red/BODIPY-based bimodal probe sensitive to changes in the micropolarity and microviscosity of the endoplasmic reticulum.

We herein report a fluorescent bimodal probe (1) capable of determining ER viscosity and polarity changes using FLIM and fluorescence ratiometry, respectively; during ER stress caused by tunicamycin, the viscosity was increased from ca. 129.5 to 182.

Rational design of biotin-disulfide-coumarin conjugates: a cancer targeted thiol probe and bioimaging.

Biotin-disulfide-coumarin conjugates are designed and synthesized as novel fluorescent sensors for cancer targeted intracellular thiol imaging in living organisms. In vitro experiments disclose that probe 6 is preferentially taken up by biotin receptor-positive A549 tumor cells through receptor mediated endocytosis.

Molecular modulated cysteine-selective fluorescent probe.

We have synthesized a series of coumarins (1-3) that can emit fluorescence in a turn-on manner through a Michael-type reaction with thiol-containing compounds. The only difference among the coumarins is the position of a carboxyl group on its benzene ring moiety near the double-bond conjugated coumarin. Their selectivity for Cys, GSH, and Hcy as well as the associated fluorogenic mechanism were illustrated by fluorescence spectroscopy, DFT calculations, and kinetic studies.

Cu2+-induced intermolecular static excimer formation of pyrenealkylamine.

Synthesis of monopyrenylalkylamine derivative 1 and its fluorescence behavior for Cu2+ in H2O/CH3CN (1:1, v/v) were investigated. Upon Cu2+ binding, 1, bearing a sulfonamide group, exhibited a marked excimer emission at 455 nm along with a weak monomer emission at 375 nm. The excimer emission, driven by formation of an intermolecular pyrenyl static excimer upon Cu2+ binding to the sulfonamide group, is rationalized by experimental and theoretical DFT calculation results.

UV band Splitting of chromogenic azo-coupled calix[4]crown upon cation complexation.

Calixcrown-6 compounds carrying a pair of phenylazo moieties on the upper rim and two OH groups, one OH group, and two OR groups on the lower rim have been prepared in both the cone and partial cone conformations. UV/vis spectral measurements showed a red shift upon the addition of Ca2+ to the calixcrown carrying two OH groups and a blue shift for the calixcrown carrying two OR groups. For the compounds with two OR groups on the lower rim and a fixed partial cone conformation, a blue shift caused by electrostatic interaction between the oxygen atoms of OR and the metal ion as well as a red shift caused by the pi-metal complexation between the rotated calix benzene and the metal ion were observed.