Chemotherapy (doublet or triplet) plus targeted therapy by RAS status as conversion therapy in colorectal cancer patients with initially unresectable liver-only metastases. The UNICANCER PRODIGE-14 randomised clinical trial.

Background: Colorectal cancer (CRC) patients have a better prognosis if metastases are resectable. Initially, unresectable liver-only metastases can be converted to resectable with chemotherapy plus a targeted therapy. We assessed which of chemotherapy doublet (2-CTx) or triplet (3-CTx), combined with targeted therapy by RAS status, would be better in this setting.

Rationale and Design of the IROCAS Study: Multicenter, International, Randomized Phase 3 Trial Comparing Adjuvant Modified (m) FOLFIRINOX to mFOLFOX6 in Patients With High-Risk Stage III (pT4 and/or N2) Colon Cancer-A UNICANCER GI-PRODIGE Trial.

Background: According to the IDEA trial, 6-month adjuvant chemotherapy should remain the treatment standard in stage III T4 or N2 colon cancer. The relatively poor survival in this high-risk subgroup-a 3-year disease-free survival (DFS) rate of 65%-and the potential synergistic efficacy of 5-fluorouracil (5-FU), oxaliplatin, and irinotecan suggest that FOLFIRINOX may be a regimen of particular interest in this setting.

Patients And Methods: This multicenter international phase 3 trial (ClinicalTrials.

A transvaginal ultrasound study comparing transobturator tape and tension-free vaginal tape after surgical treatment of female stress urinary incontinence.

This study was carried out to compare ultrasonographic findings on patients after transobturator tape (TOT) and tension-free vaginal tape (TVT) procedures to evaluate displacement of tapes up to a 2-year follow-up and to test the correlation between bladder outlet obstruction and the tape position. Forty-nine patients had a transvaginal ultrasonographic evaluation after TOT (n=31) or TVT (n=18) procedures. Twenty-one patients from the TOT group and 12 from the TVT group had ultrasonographic evaluation both at 1 and 2 years follow-up.

[Effect of pregnancy and delivery on the function of the cervico-urethral closure. II. Retrospective study on late consequences of obstetrical trauma].

Adding together the obstetric histories and the urodynamic investigations carried out on 178 incontinent women has made it possible for the authors to work out the role that obstetric trauma can play in urinary symptoms. They are able to demonstrate the effects of repeated normal deliveries and also the results of traumata over and above those that occur physiologically and are sometimes undergone by the perineum.

[Effect of pregnancy and delivery on the function of the cervico-urethral closure. I. Prospective study of 27 women].

Urinary incontinence is a complication of pregnancy. Having carried out urodynamic studies in pregnancy and immediately after delivery in 27 primigravid women, the authors have been able to clarify the alterations that take place in narrowing and closing the neck of the bladder and urethra, and especially in the tone of the urethra and of the functional character of the organ, in connection with hormonal changes that occur in pregnancy. They also demonstrate an increasing instability of the bladder which is due to compression by the pregnant uterus and which makes the function of bladder neck closure more difficult.

[Involuntary leakage of urine in women].

Involuntary leakage of urine in women is often the result of ill-understood pathological conditions which, it seems to us, can most often be related to neurological troubles or to post-operative urethral scarring with or without weak sphincter action associated with urethral instability. They are responsible for a large fraction of the poor results that have been obtained after treatment of bladder instability or of urinary incontinence due to the transmission defect. They should be looked for carefully in every pre-treatment work-out of a patient.

[Interest of urodynamic exploration in the women with prolapsus].

In a retrospective study of 54 cases of prolapse in the menopausal woman the authors noted problems of urinary continence, in particular stress incontinence and incontinence due to bladder instability, in 40 p. cent of these women. Unfortunately, the clinical diagnosis is often misleading, and is in 65 p.