Publications by authors named "Joud Hijazi"
The generalization of fear is adaptive in that it allows an animal to respond appropriately to novel threats that are not identical to previous experiences. In contrast, the overgeneralization of fear is maladaptive and is a hallmark of post-traumatic stress disorder (PTSD), a psychiatric illness that is characterized by chronic symptomatology and a higher incidence in women compared to men. Therefore, understanding the neural basis of fear generalization at remote time-points in female animals is of particular translational relevance.
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- TIA1 is an RNA-binding protein linked to neurodegenerative diseases, but its functions in normal brain activity, specifically in the hippocampus, are not well understood.
- Studies show that TIA1 can either enhance or inhibit stress-related synaptic plasticity, affecting behaviors like conditioned odor avoidance and contextual fear memory.
- The research highlights TIA1's role in regulating a network of immune-related genes that influence memory and could have implications for understanding stress-related psychiatric disorders like PTSD and anxiety.