Publications by authors named "Jou Glasheen"
There is an urgent need to discover and progress anti-infectives that shorten the duration of tuberculosis (TB) treatment. Mycobacterium tuberculosis, the etiological agent of TB, is refractory to rapid and lasting chemotherapy due to the presence of bacilli exhibiting phenotypic drug resistance. The charcoal agar resazurin assay (CARA) was developed as a tool to characterize active molecules discovered by high-throughput screening campaigns against replicating and non-replicating M.
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- The search for effective drugs against Mycobacterium tuberculosis faces challenges due to costly and time-consuming testing methods for both replicating and nonreplicating bacteria.
- Researchers developed a new testing method called the charcoal agar resazurin assay (CARA), which allows for quicker and more efficient differentiation of bactericidal and bacteriostatic activities in antimycobacterial compounds.
- Testing revealed that two known TB drugs, PA-824 (pretomanid) and TMC207 (bedaquiline), primarily exhibit bacteriostatic properties rather than bactericidal ones.