Publications by authors named "Jost Luenstedt"
Article Synopsis
- The study investigates how partial hepatectomy (pHx), a common surgical procedure for colorectal liver metastasis in Stage IV colorectal cancer (CRC), influences tumor progression at a molecular level using a mouse model.
- Mice that underwent pHx showed significant liver growth and a higher metastatic load compared to control mice, indicating that pHx may enhance the spread of CRC to the liver rather than simply removing existing tumors.
- The findings suggest that pHx triggers inflammatory responses and tissue changes in the liver, creating an environment that promotes the establishment of new metastatic tumors, highlighting the need for a better understanding of post-surgery cancer dynamics.
Metastasized colorectal cancer (CRC) is associated with a poor prognosis and rapid disease progression. Besides hepatic metastasis, peritoneal carcinomatosis is the major cause of death in Union for International Cancer Control (UICC) stage IV CRC patients. Insights into differential site-specific reconstitution of tumor cells and the corresponding tumor microenvironment are still missing.
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