A new approach to 'on-demand' treatment of lifelong premature ejaculation by treatment with a combination of a 5-HT receptor antagonist and SSRI in rats.

Lifelong premature ejaculation (PE) in men lacks an adequate on-demand pharmacological treatment. Although selective serotonin reuptake inhibitors (SSRIs) are used for PE they only work after chronic treatment, or if used on-demand, less adequately than chronic SSRI treatment. It has been shown that the addition of a behaviorally silent 5-HT-receptor antagonist to an SSRI can generate acute inhibitory effects on male rat sexual behavior.