Publications by authors named "Josiah T Sucic"
Article Synopsis
- Astrocytes are important for cognitive health and play a dual role in Alzheimer's disease, influenced by the transcription factor NF-κB.
- Studies combining human brain samples and animal models revealed that NF-κB activity in astrocytes is linked to Alzheimer's pathology, showing higher levels of certain NF-κB variants in affected individuals.
- Chronic activation of NF-κB in healthy brains disrupts protein balance and induces inflammation, while inhibition in Alzheimer's models leads to increased plaque buildup, highlighting NF-κB's complex role in neuroprotection and neurotoxicity.
