Preclinical Evaluation of Inhalational Spectinamide-1599 Therapy against Tuberculosis.

The lengthy treatment time for tuberculosis (TB) is a primary cause for the emergence of multidrug resistant tuberculosis (MDR-TB). One approach to improve TB therapy is to develop an inhalational TB therapy that when administered in combination with oral TB drugs eases and shortens treatment. Spectinamides are new semisynthetic analogues of spectinomycin with excellent activity against (), including MDR and XDR strains.

Pharmacokinetics of Monoclonal Antibodies.

Monoclonal antibodies (mAbs) have developed in the last two decades into the backbone of pharmacotherapeutic interventions in a variety of indications, with currently more than 40 mAbs approved by the US Food and Drug Administration, and several dozens more in clinical development. This tutorial will review major drug disposition processes relevant for mAbs, and will highlight product-specific and patient-specific factors that modulate their pharmacokinetic (PK) behavior and need to be considered for successful clinical therapy.

Pharmacokinetics of ponazuril after oral administration to healthy llamas (Lama glama).

Objective: To determine the pharmacokinetics after oral administration of a single dose of ponazuril to healthy llamas.

Animals: 6 healthy adult llamas.

Procedures: Ponazuril (20 mg/kg) was administered once orally to 6 llamas (day 0).