Publications by authors named "Josiah Otwoma Gichana"
Article Synopsis
- The WHO recommends integrase strand transfer inhibitors (INSTIs) as first-line treatment for HIV, but there's limited data on drug resistance in resource-limited settings like Cameroon.
- In a study of 56 INSTI-naive patient viral sequences from Cameroon, researchers analyzed 37 high-quality sequences, finding the majority belonged to the CRF02_AG subtype.
- The analysis revealed that 18.9% of the sequences had resistance-associated mutations (RAMs), with only 5.4% showing major RAMs that could affect treatment, highlighting the need for further monitoring in resource-limited areas.
Introduction: The emergence of drug resistance mutations (DRMs) has been a major threat for successful lifelong combination antiretroviral therapy (cART), especially for HIV-vertically infected children within the context of the prevention of mother-to-child transmission (PMTCT). This study aimed to evaluate DRMs amongst immune competent treatment-naïve children in Cameroon.
Methods: A cross-sectional study was conducted between 2015 and 2016 amongst 55 proxy consented HIV-1 positive children, aged 9 months to 6 years.