The role of myeloid cell heterogeneity during spontaneous choroidal neovascularization in Vldlr knockout mice.

Background: Myeloid cells are heterogeneous cells that are critical for spontaneous choroidal neovascularization (CNV) in the Vldlr mouse model. However, the specific myeloid cell subtype necessary for CNV remains unknown.

Methods And Results: To investigate the role of monocytes, we bred Ccr2 and Nr4a1 mice into the Vldlr background.