Publications by authors named "Joshua W Ogony"
Article Synopsis
- Obesity is linked to higher rates of breast cancer incidence, recurrence, and death, with specific cells in fat tissue (adipocytes and ASCs) contributing to early cancer progression.
- Researchers created models of human breast tumors with fat tissue showing various changes due to obesity to study how cancer cells escape into circulation.
- The study found that both lean and obese fat cells equally sped up the escape of breast cancer cells, indicating that the presence of these fat cells, regardless of obesity, enhances cancer cell mobility.
The etiology of triple-negative breast cancers (TNBC) is poorly understood. As many TNBCs develop prior to the initiation of breast cancer screening or at younger ages when the sensitivity of mammography is comparatively low, understanding the etiology of TNBCs is critical for discovering novel prevention approaches for these tumors. Furthermore, the higher incidence rate of estrogen receptor-negative breast cancers, and specifically, of TNBCs, among young African American women (AAW) versus white women is a source of racial disparities in breast cancer mortality.
View Article and Find Full Text PDFThe transcription factors Sox2, Oct4, and Nanog regulate within a narrow dose-range embryonic stem (ES) cell pluripotency and cell lineage commitment. Excess of Oct4 relative to Sox2 guides cells to mesoendoderm (ME), while abundance of Sox2 promotes neuroectoderm (NE) formation. Literature does not address whether ethanol interferes with these regulatory interactions during neural development.
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