Publications by authors named "Joshua W Goyert"

Context: Asylum seekers face significant and unique healthcare challenges, requiring healthcare practitioners, specifically in primary care, to be trained to care for this patient population. However, there is limited understanding of medical students' interest in and future ability to care for the population of asylum seekers in the United States.

Project Aims: We aim to understand U.

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Article Synopsis
  • Colorectal cancer (CRC) manipulates local iron handling, with hepcidin being activated in CRC, leading to increased tumor growth and size when ferroportin is deleted.
  • Mice lacking hepcidin in the colon show fewer and smaller tumors, while excessive intracellular iron worsens these parameters, indicating that iron is crucial for CRC progression.
  • The study highlights that CRC prioritizes iron for nucleotide production, and altering iron levels affects mitochondrial function and nucleotide synthesis, presenting potential targets for CRC treatments.
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Cancer cells reprogram cellular metabolism to maintain adequate nutrient pools to sustain proliferation. Moreover, autophagy is a regulated mechanism to break down dysfunctional cellular components and recycle cellular nutrients. However, the requirement for autophagy and the integration in cancer cell metabolism is not clear in colon cancer.

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Preterm birth (PTB) is a leading cause of neonatal death worldwide. Intrauterine and systemic infection and inflammation cause 30-40% of spontaneous preterm labor (PTL), which precedes PTB. Although antibody production is a major immune defense mechanism against infection, and B cell dysfunction has been implicated in pregnancy complications associated with PTL, the functions of B cells in pregnancy are not well known.

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