Current guidelines for managing asymptomatic severe aortic stenosis (AS) patients are unclear due to insufficient data on their natural history.
A systematic review and meta-analysis of 46 studies with 9,545 patients indicated that almost half experienced significant cardiovascular events within 5 years, with many developing symptoms or requiring surgery.
The findings highlight the need for better understanding and management strategies for these patients, given their poor long-term cardiovascular outcomes.
* A thorough search of clinical trial databases revealed 111 studies with over 103,000 patients, focusing on differences in outcomes for type 1 and type 2 diabetes.
* Results indicated that while SGLT1/2 inhibitors reduced the risk of heart attack and stroke in type 2 diabetes patients, SGLT2 inhibitors were more effective at lowering HbA1c levels; however, SGLT1/2 inhibitors had a higher risk of