Publications by authors named "Joshua T Sabitsky"
Article Synopsis
- UCL injuries have increased significantly over the past 30 years, with limited epidemiological studies focused on regional data.
- The study utilized a national claims database to examine UCL injury rates and surgical trends from 2010 to 2019 among male patients aged 10 to 34.
- Findings indicate that most UCL injuries occurred in the 15-19 age group, while the 20-24 age group had higher surgery rates and a trend of delayed interventions, highlighting the need for continued injury prevention strategies for younger athletes.
Purpose: To quantify cellular senescence in supraspinatus tendon and subacromial bursa of humans with rotator cuff tears and to investigate the in vitro efficacy of the senolytic dasatinib + quercetin (D+Q) to eliminate senescent cells and alter tenogenic differentiation.
Methods: Tissue was harvested from 41 patients (mean age, 62 years) undergoing arthroscopic rotator cuff repairs. In part 1 (n = 35), senescence was quantified using immunohistochemistry and gene expression for senescent cell markers (p16 and p21) and the senescence-associated secretory phenotype (SASP) (interleukin [IL] 6, IL-8, matrix metalloproteinase [MMP] 3, monocyte chemoattractant protein [MCP] 1).