Publications by authors named "Joshua T McGuire"
Article Synopsis
- GPC3 has been identified as a potential target for diagnosing and treating hepatocellular carcinoma (HCC) due to its increased expression in HCC and absence in normal liver tissue.
- Human hepatocyte cultures from HCC patients were analyzed to study GPC3's roles using various assays, including cell migration and invasion tests after silencing GPC3.
- The study found distinct forms of GPC3 in HCC precursor cells and showed that inhibiting GPC3 led to reduced cell proliferation and increased apoptosis, suggesting GPC3 could be an effective immune-therapeutic target for HCC.
Glypican-3 (GPC-3), a transmembrane heparan sulfate proteoglycan (HSPG), has recently been investigated as a player in tissue-dependent cellular signaling, specifically as a regulator of growth. Noteworthy, the regulatory protein has been implicated in both stimulatory and inhibitory pathways involving cell growth. Initially, GPC-3 was thought to act as a cell cycle regulator, as a loss-of-function mutation in the gene caused a hyper-proliferative state known as Simpson-Golabi-Behmel (SGB) overgrowth syndrome.
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