Publications by authors named "Joshua S Park"
Cytokinesis is the final stage of the cell cycle that results in the physical separation of daughter cells. To accomplish cytokinesis, many organisms build an actin- and myosin-based cytokinetic ring (CR) that is anchored to the plasma membrane (PM). Defects in CR-PM anchoring can arise when the PM lipid phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P2] is depleted.
View Article and Find Full Text PDFArticle Synopsis
- Phosphatidylinositol (PI)-4-phosphate (PI4P) is a crucial lipid located in the plasma membrane and Golgi of various cells, playing a role in cellular functions such as division.
- In Schizosaccharomyces pombe (a type of yeast), two essential enzymes, Stt4 and Pik1, produce PI4P; Stt4 is found at the plasma membrane and directly affects cell division, while Pik1 is located in the trans-Golgi and influences Golgi PI4P production.
- The study reveals that Pik1's role is distinct from Stt4; disruption of Pik1 leads to decreased plasma membrane PI4P levels, emphasizing the critical role of PM PI
Article Synopsis
- Phosphatidylinositol (PI)-4-phosphate (PI4P), a key lipid found in cell membranes, is produced by enzymes Stt4 and Pik1, which are vital for cellular processes.
- * Stt4 is essential for generating PI4P and PI(4,5)P at the plasma membrane, influencing how cells divide.
- * Pik1, localized in the trans-Golgi, primarily contributes to PI4P production but does not directly impact cytoskeletal functions like cytokinesis.
Purpose: To determine whether time interval between hemi-thyroidectomy and subsequent completion thyroidectomy impacts outcomes.
Methods: Retrospective review of 68 patients having completion thyroidectomy from August 2012 to December 2019. Patients were separated into two groups based on the time interval between surgeries: early (≤10 days) or delayed (≥90 days).
Objectives: To determine the prevalence of separate and combined voice and swallowing impairments before and after total thyroidectomy and to delineate risk factors for these symptoms.
Methods: Retrospective review of 592 consecutive patients who underwent total thyroidectomy from July 2003 to August 2015.
Results: Combined voice and swallowing problems occurred preoperatively in 4.
Background: While use of total thyroidectomy has increased in management of hyperthyroidism, concerns exist about increased surgical complication rates; most notably, hematoma, recurrent laryngeal nerve (RLN) injury, and hypocalcemia.
Methods: Retrospective cohort study of 454 patients undergoing total thyroidectomy between 2003 and 2015. All patients had surgery for hyperthyroidism, benign euthyroid disease, or thyroid malignancy.
In this study, multi-parametric magnetic resonance imaging (MRI) was conducted to monitor skeletal muscle changes in dystrophic (mdx4cv) and age-matched control (C57BL/6J) mice starting at 3 weeks of age. The objective of this study was to evaluate and characterize changes in muscle tissue characteristics of hind limbs in young, dystrophic mice using MRI. Mdx4cv (n = 25) and age-matched C57BL/6J (n = 5) were imaged at 3, 5, 7, 9, and 11 weeks of age.
View Article and Find Full Text PDFTo our knowledge this is the first systematic review of tracheal chondrosarcoma treatment outcomes. Management insights are thoroughly discussed. Men constitute 93.
View Article and Find Full Text PDFPurpose: The study aimed to provide precise measurements of anterior mandibular structural anatomy and to explore potential osteotomies for genioglossal advancement.
Methods: Cone beam computed tomography was used to analyze 33 randomly selected patients undergoing surgery for obstructive sleep apnea (OSA) between 2014 and 2016 at an academic surgical hospital. The locations of relevant mandibular structures were measured and statistical modeling was performed.
Objectives/hypothesis: To assess the effect of genioglossus, geniohyoid, and anterior digastric muscle advancement on base of tongue and hyoid position.
Study Design: Cadaver experiments.
Methods: In fresh cadavers, the mandibular attachments of the genioglossus, geniohyoid, and anterior digastric muscles were advanced anteriorly by 6, 10, or 14 mm, and the anterior displacement of the base of tongue and hyoid was measured.