Small molecule organic eutectics as candidates to replace plastics.

Legislative change and shifting consumer sentiment drive a need to replace polymers in certain products. Herein, we highlight that eutectic molecular glasses and liquids are promising but underutilized candidate materials. We formulate a series of hydrophobic eutectic molecular liquids and glasses by mixing their crystalline components.

Total bilirubin assay differences may cause inconsistent treatment decisions in neonatal hyperbilirubinaemia.

Objectives: To assess interlaboratory variability of total serum bilirubin (TSB) results in newborns. Initiated following a clinical incident in which a neonate was transferred to a tertiary hospital for treatment of severe hyperbilirubinemia but on arrival was reclassified into a lower risk category due to a 20% difference in TSB between laboratories.

Methods: Fresh residual plasma samples from hospital-born infants were pooled to obtain 11 samples across a range of total bilirubin concentrations.

PET and SPECT Imaging of the Brain: History, Technical Considerations, Applications, and Radiotracers.

Advances in nuclear medicine have revolutionized our ability to accurately diagnose patients with a wide array of neurologic pathologies and provide appropriate therapy. The development of new radiopharmaceuticals has made possible the identification of regional differences in brain tissue composition and metabolism. In addition, the evolution of 3-dimensional molecular imaging followed by fusion with computed tomography and magnetic resonance imaging have allowed for more precise localization of pathologies.

Common Ingroup Identity, Perceived Similarity, and Communal Interracial Relationships.

Integrating theory on interpersonal relationships and intergroup relations, this research examined the role of common ingroup recategorization (i.e., perceiving outgroup members as belonging to the same superordinate group as oneself) in fostering communal interracial relationships.

Impact of Lung Parenchymal-Only Failure on Overall Survival in Early-Stage Lung Cancer Patients Treated With Stereotactic Ablative Radiotherapy.

Introduction: The impact of lung parenchymal-only failure on patient survival after stereotactic ablative body radiotherapy (SABR) for early-stage non-small-cell lung cancer (NSCLC) remains unclear.

Patients And Methods: The study population included 481 patients with early-stage NSCLC who were treated with 3- to 5-fraction SABR between 2000 and 2016. The primary study objective was to assess the impact of out-of-field lung parenchymal-only failure (OLPF) on overall survival (OS).

Pursuing interpersonal value: An interdependence perspective.

The current research examined the interpersonal implications of pursuing goals to be valued by others as a relationship partner, termed interpersonal value goals. Across 3 experiments, a large cross-sectional study, 2 daily experience studies, and a 1-year longitudinal study with behavioral observation of conflict interactions, the pursuit of interpersonal value was associated with higher quality interactions and relationships, as suggested by multiple outcomes, including responsive and prosocial behavior, adoption of compassionate goals, confidence in being valued, more positive sentiments from interaction and relationship partners, and judgments of relationship quality. Relationship commitment predicted adoption of interpersonal value goals, which partially mediated effects of commitment on these outcomes.

PET/MRI vs PET/CT in Head and Neck Imaging: When, Why, and How?

The increasing availability of hybrid PET/MRI systems has led to a breadth of new publications and opportunities for use of PET/MRI. While PET/CT has been a valuable tool for oncologic staging, including head and neck malignancy, there are several theoretical and practical advantages a PET/MRI system would have over PET/CT in head and neck imaging. This review article discusses the established role of PET/CT, early evidence for the role of PET/MRI, and protocol considerations for both PET/CT and PET/MRI as they apply to head and neck imaging.

Validation of negativity: Drawbacks of interpersonal responsiveness during conflicts with outsiders.

The current research included 7 studies testing a model of interpersonal processes when people disclose to their close relationship partners ("confidants") about their conflicts involving adversaries outside the dyad. The model posits that confidants who feel close to disclosers tend to adopt goals to be responsive to disclosers during these interactions, which motivates them to validate disclosers' negativity toward their adversaries. Disclosers interpret this validation of negativity as responsive, which motivates them to continue confiding in these confidants, but also respond to this behavior with more negative moral evaluations of their adversaries, reduced willingness to forgive their adversaries, and reduced commitment to maintaining a relationship with their adversaries.

Transcatheter microwave ablation can deliver deep and circumferential perivascular nerve injury without significant arterial injury to provide effective renal denervation.

Background: Clinical studies of transcatheter radiofrequency renal denervation for treating hypertension have been hampered by the lack of consistent denervation efficacy. We aimed to demonstrate the short-term efficacy and safety of transcatheter microwave renal denervation.

Methods: A novel 7F microwave system was validated in a sheep model of unilateral renal denervation.

Delayed Temporal Lobe Hemorrhage After Initiation of Acyclovir in an Immunocompetent Patient with Herpes Simplex Virus-2 Encephalitis: A Case Report.

Herpes simplex virus (HSV) is the most common cause of non-epidemic, sporadic, acute focal encephalitis in the United States. Inflammation of the vasculature makes them friable and susceptible to hemorrhage. Massive hemorrhage, though rare, can present in a delayed fashion after initiation of acyclovir and often requires surgical intervention.

Mobile Schwannoma of the Lumbar Spine: A Case Report and Review of the Literature.

Mobile schwannomas of the spine have been sparsely documented in the literature. In cases referred to in existing literature, the migratory schwannoma was documented to occur in the lumbar spine. We added another case to the small available literature.

Bilateral Subaxial Rotational Vertebral Artery Occlusion in a Setting of a Prior Cervical Construct.

Background: Rotational vertebral artery occlusion, or bow hunter's syndrome, most commonly affects the C1-2 level because of its importance in regulating rotational movement.

Case Description: A 50-year-old man with increasing neck pain and severe symptoms of vertebrobasilar insufficiency with bidirectional head rotation had undergone several prior subaxial cervical spine operations. Dynamic cerebral angiography demonstrated complete occlusion of the left vertebral artery during head rotation to the right and complete occlusion of the right vertebral artery during head rotation to the left.

Endoscope-Assisted Combined Supracerebellar Infratentorial and Endoscopic Transventricular Approach to the Pineal Region: A Technical Note.

Neoplasms of the pineal region comprise less than 2% of all intracranial lesions. A variety of techniques have been adapted to gain access to the pineal region. Classic approaches employ the use of the microscope.

Simultaneous Transventricular-Orbitocranial Resection of Large Suprasellar Craniopharyngioma as Inspired by Jackson's Maneuver from 1863.

Traditional skull base techniques utilizing the microscope have allowed surgeons improved safe access to deep-seated lesions. More recent technical advances with the endoscope have allowed improved visibility and access to these previously difficult-to-reach regions. Most current literature emphasizes one technique over the other.

Osteonecrosis of the Torus Palatinus in the Setting of Long-Term Oral Bisphosphonate Use--A Case Report.

Bisphosphonates are medications used orally and intravenously for a variety of conditions including cancer metastatic to bone, hypercalcemia of malignancy, Paget's disease and osteoporosis. Osteonecrosis of the jaw has been related to bisphosphonate use. Osteonecrosis of the jaw most commonly occurs in the setting of intravenous bisphosphonate use and concomitant dental work or trauma.

Familial dysalbuminaemic hyperthyroxinaemia: a rapid and novel mass spectrometry approach to diagnosis.

Background: Familial dysalbuminaemic hyperthyroxinaemia is an important cause of discordant thyroid function test results (due to an inherited albumin variant); however, the diagnosis can be challenging. A 51-year-old man had persistently elevated free thyroxine (T4), with discordant normal thyroid-stimulating hormone and normal free triiodothyronine. He was clinically euthyroid and had a daughter with similar thyroid function test results.

Falsely elevated plasma selenium due to gadolinium contrast interference: a novel solution to a preanalytical problem.

Background: Trace elements are commonly measured by inductively coupled mass spectrometry (ICP-MS). A 30-year-old man had a plasma selenium (Se) concentration on ICP-MS of 66 µmol/L (reference interval 0.45-1.

An audit of oral glucose tolerance tests at a large teaching hospital: indications, outcomes and confounding factors.

Background: Australian guidelines on the diagnosis of diabetes mellitus (DM) recommend performing an oral glucose tolerance test (OGTT) in people with fasting plasma glucose (FPG) values of 5.5-6.9 mmol/L.

Salivary paracetamol: evaluation of a colorimetric method in assessing deliberate self-poisoning.

Background: In the laboratory evaluation of suspected paracetamol poisoning, a non-invasive sample type that avoids venepuncture would be an attractive alternative to plasma, particularly in the paediatric setting. Salivary paracetamol measurement has not previously been evaluated in the published medical literature in the setting of deliberate self-poisoning (DSP).

Methods: In-house validation experiments (recovery, stability and lower limit-of-detection) were performed on pooled saliva samples using a Roche Acetaminophen assay on a Roche/Hitachi 917 analyser.