Functional Heatmap: an automated and interactive pattern recognition tool to integrate time with multi-omics assays.

Background: Life science research is moving quickly towards large-scale experimental designs that are comprised of multiple tissues, time points, and samples. Omic time-series experiments offer answers to three big questions: what collective patterns do most analytes follow, which analytes follow an identical pattern or synchronize across multiple cohorts, and how do biological functions evolve over time. Existing tools fall short of robustly answering and visualizing all three questions in a unified interface.

Centennial record of anthropogenic impacts in Galveston Bay: Evidence from trace metals (Hg, Pb, Ni, Zn) and lignin oxidation products.

During the 20th century the impacts of industrialization and urbanization in Galveston Bay resulted in significant shifts in trace metals (Hg, Pb, Ni, Zn) and vascular plant biomarkers (lignin phenols) recorded within the surface sediments and sediment cores profile. A total of 22 sediment cores were collected in Galveston Bay in order to reconstruct the historical input of Hg, Pb, Ni, Zn and terrestrial organic matter. Total Hg (T-Hg) concentration ranged between 6 and 162 ng g in surface sediments, and showed decreasing concentrations southward from the Houston Ship Channel (HSC) toward the open estuary.

Synthesis of crystalline skutterudite superlattices using the modulated elemental reactant method.

A series of samples ((AB)(x)(CD)(y))(z) were prepared containing both short repeat units (AB and CD) and long repeat units ((AB)(x)(CD)(y)), where the short repeat units were designed to have the composition appropriate to form square M(4)Sb(12) skutterudites (M = Fe, Co, or Ir; square = vacancy, La, or Y). X-ray diffraction and reflectivity were used to follow the evolution of the films from amorphous, layered materials to crystalline skutterudite superlattices as a function of annealing temperature and time. In all cases, the short repeat units interdiffused and crystallized the expected skutterudite, while the long repeat period persisted after annealing.

Suppression of binary nucleation in amorphous La-Fe-Sb mixtures.

The nucleation energy of a series of La(x)Fe(y)Sb(z) modulated elemental reactants was measured as a function of the Fe/Sb ratio over a large composition range while holding the La content constant. The nucleation energy of the ternary compound La(0.5)Fe(4)Sb(12) with the skutterudite crystal structure was found to depend very strongly on the Fe/Sb ratio in the modulated elemental reactant, with a higher nucleation energy as the Fe/Sb ratio is moved away from the 1:3 stoichiometric value.

Synthesis of the new metastable skutterudite compound NiSb(3) from modulated elemental reactants.

A new metastable binary compound with the skutterudite crystal structure has been synthesized from modulated elemental reactants, through an amorphous intermediate, using a novel low-temperature synthesis technique. The amorphous reaction intermediate undergoes nucleation at 87 degrees C, an extremely low temperature for solid-state reactions. When heated above 350 degrees C, the metastable phase NiSb(3) disproportionates into the thermodynamically stable phases NiSb(2) and Sb.