Publications by authors named "Joshua R Paris"
Article Synopsis
- Next-generation sequencing has greatly increased data on enzyme sequences, many of which are unstudied but could enhance understanding of enzyme evolution.
- Integrating teaching and research in college can help characterize numerous enzymes, particularly focusing on SABATH methyltransferases that convert salicylic acid into methyl salicylate.
- The study shows that there's a strong conservation of substrate preference in SA methyltransferases, with specific genetic features influencing their function, but many sequences still await analysis, indicating vast potential for future research.
Purpose: The adult mammalian retina is typically incapable of regeneration when damaged by disease or trauma. Restoration of function would require generation of new adult neurons, something that until recently, mammals were thought to be incapable of doing. However, previous studies from this laboratory have shown that the α7 nicotinic acetylcholine receptor (α7 nAChR) agonist, PNU-282987, induces cell cycle reentry of Müller glia and generation of mature retinal neurons in adult rats, in the absence of detectible injury.
View Article and Find Full Text PDF