Survival Times of Patients With Menetrier's Disease and Risk of Gastric Cancer.

Background & Aims: Menetrier's disease is a rare acquired disorder associated with giant gastric folds along with protein-losing enteropathy, low stomach acid, or achlorhydria, and histologic features of massive foveolar hyperplasia. Little is known about the etiology, clinical features, or epidemiology of this disorder, including risk of gastric cancer. We investigated the outcomes and characteristics of patients with Menetrier's disease, including development of gastric cancer and survival times.

The role of cellular senescence in the gastrointestinal mucosa.

Cellular senescence is a biologically irreversible state of cell-growth arrest that occurs following either a replicative or an oncogenic stimulus. This phenomenon occurs as a response to the presence of premalignant cells and appears to be an important anticancer mechanism that keeps these transformed cells at bay. Many exogenous and endogenous triggers for senescence have been recognized to act via genomic or epigenomic pathways.

Diagnostic performance of two confocal endomicroscopy systems in detecting Barrett's dysplasia: a pilot study using a novel bioprobe in ex vivo tissue.

Background: There are currently 2 existing confocal laser endomicroscopy (CLE) platforms: probe-based CLE (pCLE) and endoscope-based CLE (eCLE) systems, each with its own criteria for identifying dysplasia in Barrett's esophagus (BE). The diagnostic performance of these 2 systems has not been directly compared.

Design: Preclinical, feasibility study.

The role of allergy evaluation in adults with eosinophilic esophagitis.

Background: Allergy evaluation and skin prick testing for foods are recommended in all patients with eosinophilic esophagitis. However, the yield of allergy evaluation in adult eosinophilic esophagitis is not known.

Goals: To determine the yield of allergy evaluation in adults with eosinophilic esophagitis.