Publications by authors named "Joshua Parrish"
Importance: Prostate cancer (PC) care has evolved rapidly as a result of changes in prostate-specific antigen testing, novel imaging, and newer treatments. The impact of these changes on PC epidemiology and racial disparities across disease states remains underexplored.
Objective: To characterize racial and ethnic differences in the epidemiology of PC states, including nonmetastatic hormone-sensitive PC (nmHSPC), metastatic HSPC (mHSPC), nonmetastatic castration-resistant PC (nmCRPC), and metastatic CRPC (mCRPC).
Background: For metastatic and certain advanced prostate cancer (PC), guidelines support intensified androgen deprivation therapy (ADT) as first-line (1L) systemic treatment for improved outcomes. However, some patients receive ADT alone, leading to tumor progression requiring 2nd line therapy. Despite significant racial disparities in PC outcomes, there are no population-level studies assessing racial differences in time to subsequent treatment after 1L ADT.
View Article and Find Full Text PDFBackground: Certain widely used pathological outcome prediction models that were developed in tertiary centers tend to overpredict outcomes in the community setting; thus, the Michigan Urological-Surgery Improvement Collaborative (MUSIC) model was developed in general urology practice to address this issue. Additionally, the development of these models involved a relatively small proportion of Black men, potentially compromising the accuracy of predictions in this patient group. We tested the validity of the MUSIC and three widely used nomograms to compare their overall and race-stratified predictive performance.
View Article and Find Full Text PDFArticle Synopsis
- This study examined the effectiveness of blue light cystoscopy (BLC) compared to white light cystoscopy (WLC) for detecting non-muscle invasive bladder cancer (NMIBC) in 378 patients from the Veterans Affairs system.
- Results showed that BLC led to a longer median time before recurrence (40 months) compared to WLC (26 months) and significantly reduced recurrence risk (with a Hazard Ratio of 0.70).
- The study concluded that BLC is more effective in prolonging time to recurrence without significant racial disparities in outcomes among Black and White patients.