Publications by authors named "Joshua P Sevigny"
Article Synopsis
- Alcohol use disorder (AUD) is linked to binge drinking and can cause lasting changes in the brain's neurocircuitry, particularly in the extended amygdala, leading to neuroinflammation and potential relapse.
- A study using the Drinking in the Dark (DID) model in rodents found that the anti-inflammatory drug minocycline reduced binge drinking behavior without significantly affecting long-term consumption of natural rewards like food and water.
- The research also highlighted significant changes in microglia morphology in the central amygdala but not in the basolateral amygdala, indicating that targeting neuroinflammation could be a promising approach for treating AUD.
Article Synopsis
- The mammalian cortex consists of different cell types that have specific properties, which are important for understanding how the cortex functions in both health and disease.
- Researchers utilized data from mouse and human studies to identify marker genes and enhancers for various cortical cell types, creating a comprehensive set of tools for targeting these cells specifically.
- They introduced fifteen new transgenic driver lines, two new reporter lines, and over 800 enhancer AAVs, facilitating a wide range of experimental approaches to study the mammalian cortex and its functions.
An impairment in willingness to exert physical effort in daily activities is a noted aspect of several psychiatric conditions. Previous studies have supported an important role for the lateral habenula (LHb) in dynamic decision-making, including decisions associated with discounting costly high value rewards. It is unknown whether a willingness to exert physical effort to obtain higher rewards is also mediated by the LHb.
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