Publications by authors named "Joshua M Varghese"
Article Synopsis
- Mauritian-origin cynomolgus macaques (MCMs) are valuable in biomedical research due to their genetic uniformity, which simplifies experimental designs.
- The study focuses on understanding immune-regulating gene families, specifically killer Ig-like receptors (KIR) and NK group 2 (NKG2), by utilizing advanced long-read sequencing to assemble their genomic haplotypes.
- The findings not only enhance knowledge of these gene clusters but also propose a cost-effective strategy for large-scale genotyping, paving the way for extensive genetic research in MCMs.
Macaques provide the most widely used nonhuman primate models for studying the immunology and pathogenesis of human diseases. Although the macaque major histocompatibility complex (MHC) region shares most features with the human leukocyte antigen (HLA) region, macaques have an expanded repertoire of MHC class I genes. Although a chimera of two rhesus macaque MHC haplotypes was first published in 2004, the structural diversity of MHC genomic organization in macaques remains poorly understood owing to a lack of adequate genomic reference sequences.
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