Methyltrimethoxysilane (MTM) as a Reagent for Direct Amidation of Carboxylic Acids.

Methyltrimethoxysilane [MTM, CHSi(OMe)] has been demonstrated to be an effective, inexpensive, and safe reagent for the direct amidation of carboxylic acids with amines. Two simple workup procedures that provide the pure amide product without the need for further purification have been developed. The first employs an aqueous base-mediated annihilation of MTM.

Silicon compounds as stoichiometric coupling reagents for direct amidation.

Despite being one of the most frequently carried out chemical reactions in industry, there is currently no amidation protocol that is regarded as safe, high yielding, environmentally friendly and inexpensive. The direct amidation of a carboxylic acid with an amine is viewed as an inherently good solution for developing such a protocol. Since the 1960s, there has been a gradual development in the use of silicon reagents for direct amidation.