Publications by authors named "Joshua Ide"
Article Synopsis
- - Osteoarthritis (OA) causes chronic pain, and while non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat this pain, they can also lead to serious side effects like gastrointestinal issues and cardiovascular problems.
- - The study aimed to assess the prevalence of comorbid conditions among OA patients and how these conditions affected NSAID prescribing patterns before and after their OA diagnosis.
- - Results showed that over 50% of OA patients had at least one comorbidity, primarily cardiovascular disease, and a significant portion of these patients were prescribed NSAIDs following their OA diagnosis.
Article Synopsis
- This study investigates how different interpretations of an observational study's design can affect the results when independent researchers attempt to reproduce it.
- The researchers found that out of ten criteria for including patients, teams only agreed, on average, 4 of 10 times, leading to significant variability in the size and characteristics of the resulting patient cohorts.
- The study concludes that providing open analytical code and a standardized data model can improve reproduction accuracy and consistency in observational research.
Introduction: Causality assessment of individual case safety reports (ICSRs) is an important step in pharmacovigilance case-level review and aims to establish a position on whether a patient's exposure to a drug is causally related to the patient experiencing an untoward adverse event. There are many different approaches for case causality adjudication, including the use of expert opinions and algorithmic frameworks; however, a great deal of variability exists between assessment methods, products, therapeutic classes, individual physicians, change of process and conventions over time, and other factors.
Objective: The objective of this study was to develop a machine learning-based model that can predict the likelihood of a causal association of an observed drug-reaction combination in an ICSR.