Publications by authors named "Joshua H Dass"
Article Synopsis
- This review focuses on treatment options for oropharyngeal squamous cell carcinoma (OPSCC), highlighting its molecular mechanisms within head and neck cancers.
- Treatment approaches can either be radical (aimed at curing the disease) or palliative (focused on disease control and relieving symptoms).
- Key findings show that radiotherapy is the primary treatment choice for OPSCC in many countries, while surgical options are limited; molecular therapies are still mainly in preclinical stages, with several drugs currently undergoing clinical testing.
Pigment epithelium-derived factor (PEDF) is a natural immunomodulator, anti-inflammatory, anti-angiogenic, anti-tumour growth and anti-metastasis factor, which can enhance tumour response to PEDF but can also conversely have pro-cancerous effects. Inflammation is a major cause of cancer, and it has been proven that PEDF has anti-inflammatory properties. PEDF's functional activity can be investigated through measuring metastatic and metabolic biomarkers that will be discussed in this review.
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