Publications by authors named "Joshua G Ring"
Microbiology (Reading)
November 2015
Article Synopsis
- - Yersinia pestis, the bacteria that causes plague, relies on the Ail protein to effectively survive and thrive in mammalian hosts, helping it attach to cells and resist immune attacks.
- - The study reveals that Ail not only interacts with several extracellular matrix components but also specifically binds to vitronectin, which plays roles in cell attachment and immune system modulation.
- - It was found that Ail-expressing strains of Y. pestis cause cleavage of vitronectin by the Pla protease, and the direct binding of Ail to vitronectin was validated through experiments using purified Ail in nanodiscs, demonstrating its crucial role in pathology.
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