Acute Presentation of Newly Diagnosed Multiple Sclerosis Associated With Polymerase Chain Reaction-Proven Human Herpesvirus 6 Central Nervous System Infection.

We present the case of a 26-year-old male who was found to have human herpesvirus 6 (HHV-6) in his cerebrospinal fluid (CSF) during acute presentation of multiple sclerosis (MS). Paresthesia of the lower extremities was his only symptom during the initial presentation, and workup for MS was not included during this evaluation. A single dose of IV steroids failed to improve his condition, and symptoms became more severe.