Effect of isoflurane on brain tissue oxygen tension and cerebral autoregulation in rabbits.

Oxygen tension (PO(2)) was measured in rabbit whisker barrel cortex using oxygen sensitive electrodes to investigate the impact of isoflurane anesthesia on oxygen autoregulation. Responses to 90s episodes of 100% oxygen inspiration were obtained from rabbits before anesthesia, and then when the animals were anesthetized with 0.5% or 1.