An Unusual Presentation of Delusional Companion Syndrome: A Case Report and Review of the Literature.

Delusional companion syndrome, an uncommon subtype of delusional misidentification syndrome, has no prior reported cases in patients with primary psychotic disorders. We report a case of delusional companion syndrome in the absence of any organic brain disease, stroke, or severe brain injury, in a young female with schizophrenia. The patient is a 29-year-old G3P3 female, with a history of schizophrenia and major depressive disorder, who, after recently losing custody of her children, presented to the pediatric emergency department for evaluation of her baby doll, which she believed to be her child because the doll wasn't eating or moving well.

Cannulated Intramedullary Screw Fixation of Distal Fibular Fractures.

Open reduction and internal fixation (ORIF) methods, primarily plates and screws, remain the standard of treatment for distal fibular fractures. This study evaluates the use of a cannulated intramedullary screw as a minimally invasive treatment method for distal fibular fractures, which has not been reported in the current literature. This retrospective study included 45 patients with distal fibular fractures treated with cannulated intramedullary screw fixation.

Haplotyping germline and cancer genomes with high-throughput linked-read sequencing.

Haplotyping of human chromosomes is a prerequisite for cataloguing the full repertoire of genetic variation. We present a microfluidics-based, linked-read sequencing technology that can phase and haplotype germline and cancer genomes using nanograms of input DNA. This high-throughput platform prepares barcoded libraries for short-read sequencing and computationally reconstructs long-range haplotype and structural variant information.

Synergistic effects within a C2-symmetric organocatalyst: the potential formation of a chiral catalytic pocket.

This study describes the synthesis of five novel C2-symmetric organocatalysts that facilitate the on-water asymmetric aldol reaction at low catalyst loading (1 mol%) without the use of additives. Each catalyst is composed of two diprolinamide units joined by a symmetric alkyl bridging group allowing for systematic modulation of catalytic site proximity. Typically, catalysts in this manuscript which bear the catalytic units in close proximity gave the best reaction outcomes in terms of conversion (up to >99%), diastereomeric ratio (4/96, syn/anti) and enantiomeric excess (up to 97%).

Investigating ionic effects applied to water based organocatalysed aldol reactions.

Saturated aqueous solutions of various common salts were examined for their effect on aqueous aldol reactions catalysted by a highly active C(2)-symmetric diprolinamide organocatalyst developed in our laboratory. With respect to the aldol reaction between cyclohexanone and 4-nitrobenzaldehyde, deionised water was always a superior medium to salt solutions though some correlation to increasing anion size and depression in enantiomeric excess could be observed. Additionally, the complete inhibition of catalyst activity observed when employing tap water could be alleviated by the inclusion of ethylenediaminetetraacetate (EDTA) into the aqueous media prior to reaction initiation.