Publications by authors named "Joshua D Froess"
Article Synopsis
- The study aimed to assess the impact of P2Y12 inhibitors, specifically ticagrelor, on critically ill COVID-19 patients, as platelet activation may be a new treatment target.
- Conducted as a randomized clinical trial, it included 949 patients who were assigned to receive either the P2Y12 inhibitor or usual care for up to 14 days.
- Results showed a small increase in organ support-free days for those on the inhibitor, but the effect was uncertain due to overlapping confidence intervals, and the trial was terminated early due to slow enrollment.
Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.
N Engl J Med
August 2021
Article Synopsis
- A clinical trial investigated whether therapeutic-dose anticoagulation could improve outcomes for critically ill patients with severe Covid-19 compared to standard thromboprophylaxis.
- The study found no significant difference in organ support-free days between the two groups, with the anticoagulation group showing a median of 1 day compared to 4 days for the usual-care group.
- The trial was halted due to a high probability of futility, with similar hospital discharge survival rates and a slightly higher occurrence of major bleeding in the anticoagulation group.