Publications by authors named "Joshua Caplin"
Article Synopsis
- Immune checkpoint inhibitors, a type of cancer treatment, can cause serious side effects, including immune-related myocarditis (irMyocarditis), which can be fatal.
- Researchers studied immune responses in the heart, tumor, and blood of 28 patients with irMyocarditis using advanced techniques like single-cell RNA sequencing and T-cell receptor (TCR) sequencing.
- Their findings showed an increase in certain immune cells in the heart tissue of irMyocarditis patients and identified specific TCR clones associated with severe cases, shedding light on the disease's biology and potential biomarkers.
Article Synopsis
- Immune checkpoint inhibitors (ICIs) can lead to serious immune-related adverse events (irAEs), with ICI-related myocarditis (irMyocarditis) being particularly dangerous and the most lethal among these events.
- Researchers explored immune responses in the heart, tumors, and blood of 28 patients with irMyocarditis compared to 23 controls, using advanced techniques like single-cell RNA sequencing and proteomics.
- Key findings revealed a unique presence of specific immune cells in irMyocarditis heart tissue, distinct T cell responses in heart vs. tumor, and identified novel biomarkers related to fatality that could inform future therapies.
Background: Non-invasive measures that can accurately estimate cardiac output may help identify volume-responsive patients. This study seeks to compare two non-invasive measures (corrected carotid flow time and carotid blood flow) and their correlations with invasive reference measurements of cardiac output. Consenting adult patients (n = 51) at Massachusetts General Hospital cardiac catheterization laboratory undergoing right heart catheterization between February and April 2016 were included.
View Article and Find Full Text PDFCardiovascular disease (CVD) remains the leading cause of morbidity and mortality in the United States. Recent studies suggest that pericardial adipose tissue (PCAT) secretes inflammatory factors that contribute to the development of CVD. To better characterize the role of PCAT in the pathogenesis of disease, we performed a large-scale unbiased analysis of the transcriptional differences between PCAT and subcutaneous adipose tissue, analysing 53 microarrays across 19 individuals.
View Article and Find Full Text PDF