Equivalence framework for an age-structured multistage representation of the cell cycle.

We develop theoretical equivalences between stochastic and deterministic models for populations of individual cells stratified by age. Specifically, we develop a hierarchical system of equations describing the full dynamics of an age-structured multistage Markov process for approximating cell cycle time distributions. We further demonstrate that the resulting mean behavior is equivalent, over large timescales, to the classical McKendrick-von Foerster integropartial differential equation.