Publications by authors named "Joshua B Ongalo"
Article Synopsis
- A study in rural Kenya found that 41% of asymptomatic residents had antibodies against the SARS-CoV-2 spike protein, and 82.5% exhibited T cell responses to multiple viral proteins, indicating some level of immunity despite not showing symptoms.
- The immune response profile in Kenyan participants was distinct from those in Europe and Asia, exhibiting strong reactions to accessory proteins rather than structural ones and a unique cytokine balance (higher IL-10 to IFN-γ ratio).
- These findings suggest that current methods of measuring COVID-19 prevalence may underestimate infections in asymptomatic populations, and highlight the potential influence of environmental factors on immune responses in Africa.
