Publications by authors named "Joshua A Mansfield"
Article Synopsis
- Reinfections of SARS-CoV-2 in the U.S. have become more common, especially during the Omicron variant period, rising from 2.7% during Delta to 28.8% in Omicron BQ.1/BQ.1.1.
- Hospitalizations and deaths linked to reinfections also increased significantly, going from 1.9% and 1.2% of COVID-19-related cases during Delta, to 17.0% and 12.3% during Omicron BQ.1/BQ.1.1.
- Younger adults (18-49 years) had higher rates of reinfections compared to older adults (≥50 years), and it's crucial to stay updated on vaccinations
Article Synopsis
- Enterotoxigenic Escherichia coli (ETEC) is a significant cause of diarrhea in young children in low- to middle-income countries, with heat-stable enterotoxin (ST) being a common variant.
- This study explored how ST affects cGMP levels in cells, cytokine production in epithelial cells, and the immune response to vaccinations, highlighting its role in altering inflammatory responses.
- Findings suggest that ST not only influences cell functions but may also dampen immune responses, indicating its potential impact on gut health and immunization effectiveness.