Miniaturized Capsule System Toward Real-Time Electrochemical Detection of H S in the Gastrointestinal Tract.

Hydrogen sulfide (H S) is a gaseous inflammatory mediator and important signaling molecule for maintaining gastrointestinal (GI) homeostasis. Excess intraluminal H S in the GI tract has been implicated in inflammatory bowel disease and neurodegenerative disorders; however, the role of H S in disease pathogenesis and progression is unclear. Herein, an electrochemical gas-sensing ingestible capsule is developed to enable real-time, wireless amperometric measurement of H S in GI conditions.

Freestanding region-responsive bilayer for functional packaging of ingestible devices.

Ingestible capsules have the potential to become an attractive alternative to traditional means of treating and detecting gastrointestinal (GI) disease. As device complexity increases, so too does the demand for more effective capsule packaging technologies to elegantly target specific GI locations. While pH-responsive coatings have been traditionally used for the passive targeting of specific GI regions, their application is limited due to the geometric restrictions imposed by standard coating methods.