Publications by authors named "Josh Sommovilla"
Article Synopsis
- - The study investigates whether early restaging with endoscopy and MRI after induction therapy in rectal cancer patients influences the final treatment outcome.
- - Analyzed data from 107 patients showed that those with better interim responses had significantly higher chances of achieving complete final responses, highlighting a potential link between early assessment and ultimate success.
- - Limitations of the study include its retrospective nature and small sample size, which might affect the reliability of the findings, particularly regarding the implications of partial responses.
Previously, we have demonstrated that genetically disrupting retinoblastoma protein (Rb) expression in enterocytes results in taller villi, mimicking resection-induced adaption responses. Rb deficiency also results in elevated insulin-like growth factor-2 (IGF-2) expression in villus enterocytes. We propose that postoperative disruption of Rb results in enhanced adaptation which is driven by IGF-2.
View Article and Find Full Text PDFSurgical options to enhance intestinal function in patients with short bowel syndrome.
Curr Opin Pediatr
June 2014
Purpose Of Review: This review will provide the practitioner with an understanding of the spectrum of nontransplant surgical options for managing patients with short bowel syndrome (SBS).
Recent Findings: Intestinal lengthening procedures are a promising therapy to allow autonomy from parenteral nutrition. The recently described serial transverse enteroplasty is an effective procedure that is easier to perform and has similar outcomes to the more standard longitudinal lengthening procedure described by Bianchi.