Publications by authors named "Josh Schiffman"
Article Synopsis
- Li-Fraumeni Syndrome (LFS) is associated with a greater risk of secondary cancers, but the specific impact of radiation therapy (RT) on this risk is not well understood.
- In a study of patients with germline TP53 mutations, 14 out of 40 identified LFS patients received RT and half of them developed subsequent malignancies, mostly within the same area treated by radiation.
- The findings suggest that these subsequent cancers were more likely to be recurrences of the original cancer rather than new malignancies caused by RT, indicating that RT can be beneficial when discussed in a multidisciplinary context.
Importance: Wild-type (WT) gastrointestinal stromal tumors (GISTs), which lack KIT and PDGFRA gene mutations, are the primary form of GIST in children and occasionally occur in adults. They respond poorly to standard targeted therapy. Better molecular and clinical characterization could improve management.
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