9-cis Retinoic acid and 1.25-dihydroxyvitamin D drive differentiation into IgA secreting plasmablasts in human naïve B cells.

Calcitriol and 9-cis retinoic acid (9cRA) play a fundamental role in shaping the adaptive immune response by altering the Ig profile and the differentiation of B cells, controlled by their corresponding nuclear receptors, VDR and RAR. Herein, after the establishment of a plasmablast differentiation culture, we investigated how both ligands modulate human naïve B cell differentiation and to which extent VDR/RXR and RAR/RXR signaling interferes. Calcitriol and 9cRA mediated activation of purified naïve B cells resulted in a strong differentiation of CD27 CD38 plasmablasts and antibody secretion.

Vitamin A controls the allergic response through T follicular helper cell as well as plasmablast differentiation.

Background: Vitamin A regulates the adaptive immune response and a modulatory impact on type I allergy is discussed. The cellular mechanisms are largely unknown.

Objective: To determine the vitamin A-responding specific lymphocyte reaction in vivo.