Publications by authors named "Josephine Savard"

Background: Gestational diabetes mellitus is a common condition known to be associated with pregnancy complications, larger fetus size and depression, and may therefore lead to increased concerns linked to childbirth. We sought to determine whether gestational diabetes mellitus is linked to fear of childbirth, and whether the possible association is mediated by depressive symptoms.

Methods: This study includes women who gave birth at the Kuopio University Hospital between 2019-2022 and had reported their level of fear of childbirth after gestational week 28 (n = 3293).

View Article and Find Full Text PDF

Background: Sexual Interest in Children (SIC) is a major risk factor for sexual offending, yet clinical trials are sparse. The present protocol outlines a randomized controlled trial (RCT) that aims to investigate the effectiveness of fluoxetine and Cognitive Behavioral Therapy (CBT) in help-seeking men with SIC.

Methods: Adult men contacting the Swedish telephone helpline PrevenTell are screened for inclusion and invited to further assessment on site.

View Article and Find Full Text PDF

Background And Aims: Compulsive sexual behavior disorder (CSBD) has been included as an impulse control disorder in the International Classification of Diseases (ICD-11). However, the neurobiological mechanisms underlying CSBD remain largely unknown, and given previous indications of addiction-like mechanisms at play, the aim of the present study was to investigate if CSBD is associated with structural brain differences in regions involved in reward processing.

Methods: We analyzed structural MRI data of 22 male CSBD patients (mean = 38.

View Article and Find Full Text PDF

Background: Compulsive sexual behaviour disorder is a new disorder in the International Classification of Diseases (ICD-11), and is associated with negative consequences in different areas of life. Evidence for pharmacological treatment of compulsive sexual behaviour disorder is weak and treatment options are limited. This proposed study will be the largest and the first randomised controlled trial comparing the efficacy and tolerability of two active drugs in compulsive sexual behaviour disorder.

View Article and Find Full Text PDF

Background And Aims: Compulsive sexual behavior disorder (CSBD) is characterized by persistent patterns of failure to control sexual impulses resulting in repetitive sexual behavior, pursued despite adverse consequences. Despite previous indications of addiction-like mechanisms and the recent impulse-control disorder classification in the International Classification of Diseases (ICD-11), the neurobiological processes underlying CSBD are unknown.

Methods: We designed and applied a behavioral paradigm aimed at disentangling processes related to anticipation and viewing of erotic stimuli.

View Article and Find Full Text PDF
Article Synopsis
  • Hypersexual disorder (HD) is a sexual desire disorder linked to impulsivity that has been studied for its potential inclusion in diagnostic manuals, with connections to HPA-axis dysregulation and cellular aging.
  • The study analyzed DNA methylation patterns from 60 HD patients and 33 healthy controls to understand the relationship between epigenetic age (EA) and HD, focusing on markers of EA acceleration and their association with dysregulation.
  • Results indicated that while baseline markers of EA were significantly elevated in participants, no specific marker of EA acceleration was definitively connected to HD or HPA-axis activity, suggesting further research is needed to clarify these relationships.
View Article and Find Full Text PDF

Guidelines for the pharmacological treatment of paraphilic disorders have historically been based on data from forensic settings and on risk levels for sexual crime. However, emerging treatment options are being evaluated for individuals experiencing distress because of their sexual urges and preferences, targeting both paraphilic disorders such as pedophilic disorder (PeD) and the new diagnosis of compulsive sexual behavior disorder (CSBD) included in the International Classification of Diseases, 11th Revision (ICD-11). As in other mental disorders, this may enable individualized pharmacological treatment plans, taking into account components of sexuality (e.

View Article and Find Full Text PDF

Background And Aims: Impulsivity is regarded as a risk factor for sexual crime reoffending, and a suggested core feature in Compulsive Sexual Behavior Disorder. The aim of this study was to explore clinical (e.g.

View Article and Find Full Text PDF

Background: Compulsive sexual behavior disorder (CSBD) is a common disorder affecting different areas of life, although studies focusing on pharmacological treatment are sparse.

Aim: To investigate whether the opioid receptor antagonist naltrexone is feasible and tolerable and can provide symptom reduction in CSBD.

Methods: Twenty men aged 27-60 years (mean = 38.

View Article and Find Full Text PDF