Publications by authors named "Josephine Marange"
Cancers (Basel)
April 2021
Article Synopsis
- A randomized crossover study was conducted to compare a new oral liquid formulation of 13-retinoic acid (13-CRA) with the current capsule method in neuroblastoma treatment, focusing on pharmacokinetics, safety, and patient satisfaction.
- The study involved 20 children, with pharmacokinetic evaluations showing that the liquid formulation’s bioavailability was 65% higher than that of the capsules, along with significant increases in maximum concentration and overall drug exposure.
- Parents reported that administering the liquid formulation was much easier, and there were no significant differences in adverse effects between the two methods.
