Publications by authors named "Josephine Louise Robb"
Brain Behav Immun
January 2025
Article Synopsis
- Lipid droplets (LD) are essential for storing triglycerides and play a significant role in regulating inflammation in cells, influenced by adipose triglyceride lipase (ATGL).
- The study examined the effects of inhibiting ATGL and the genetic loss of ATGL in microglia on inflammatory responses, particularly focusing on cytokine expression and phagocytosis during LPS-induced inflammation.
- Findings showed that ATGL inhibition led to reduced expression of pro-inflammatory cytokines (like IL-1β and IL-6), decreased inflammation-related behaviors, and altered lipid profiles, signifying ATGL's critical role in modulating neuroinflammatory responses.
