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Publications by authors named "Josephine J Kennedy"

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Lactobacillaceae differentially impact butyrate-producing gut microbiota to drive CNS autoimmunity.
Theresa L Montgomery Lucinda C Toppen Korin Eckstrom Eamonn R Heney Josephine J Kennedy

Gut Microbes

October 2024

Article Synopsis
  • Short-chain fatty acids (SCFAs), which have an anti-inflammatory effect, are reduced in multiple sclerosis (MS), with unclear reasons for their depletion in the gut microbiome.* -
  • In a study using a model for MS, it was found that certain gut bacteria can worsen symptoms by depleting SCFA-producing microbes and that increased dietary fiber can help counteract this effect.* -
  • This research suggests that managing SCFA levels in MS patients may need a combination of dietary changes and adjustments to the gut microbiome to improve health outcomes.*
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Interactions between host genetics and gut microbiota determine susceptibility to CNS autoimmunity.
Theresa L Montgomery Axel Künstner Josephine J Kennedy Qian Fang Lori Asarian

Proc Natl Acad Sci U S A

November 2020

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system. The etiology of MS is multifactorial, with disease risk determined by genetics and environmental factors. An emerging risk factor for immune-mediated diseases is an imbalance in the gut microbiome.

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Synopsis of recent research by authors named "Josephine J Kennedy"

  • - Josephine J Kennedy's research focuses on the relationship between gut microbiota and central nervous system autoimmunity, particularly in the context of multiple sclerosis (MS), highlighting the significance of short-chain fatty acids (SCFAs) produced by gut bacteria.
  • - Her recent article in "Gut Microbes" investigates how the Lactobacillaceae family of bacteria has varying effects on butyrate-producing gut microbiota, which may influence the inflammatory processes associated with CNS autoimmunity.
  • - Kennedy's earlier work published in "Proc Natl Acad Sci U S A" examines the combined roles of host genetics and gut microbiota imbalances in determining susceptibility to CNS autoimmunity, suggesting a multifactorial etiology for MS that includes both genetic and environmental influences.

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