Publications by authors named "Josephine Henry"
Background: Genome-wide association studies implicate common genetic variations in the (low-density lipoprotein receptor-related protein 1 gene) locus at risk for multiple vascular diseases and traits. However, the underlying biological mechanisms are unknown.
Methods: Fine mapping analyses included Bayesian colocalization to identify the most likely causal variant.
Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation.
David Adlam Takiy-Eddine Berrandou Adrien Georges Christopher P Nelson Eleni Giannoulatou Joséphine Henry
Nat Genet
June 2023
Article Synopsis
- * A large study identified 16 genetic risk factors for SCAD, highlighting potential genes involved in blood vessel function and the physical structure of arteries.
- * Some genetic variants linked to SCAD show opposing effects on CAD, suggesting that while both diseases share certain biological links, they operate through different pathways; high blood pressure was also found to possibly contribute to SCAD risk.
Article Synopsis
- - The study investigates the plasticity of vascular smooth muscle cells (SMCs) using induced pluripotent stem cells (iPSCs) differentiated into two types (R-SMCs and TP-SMCs) through different protocols, providing insights into their potential for cardiovascular research.
- - Both SMC types showed key smooth muscle markers, with TP-SMCs demonstrating better proliferation and migration, while R-SMCs had stronger contractile functionality linked to arterial health.
- - The findings reveal that these iPSC-derived SMC models are crucial for understanding the genetic factors contributing to major arterial diseases, with specific gene expressions and protein profiles distinguishing their roles.