Publications by authors named "Josephine H Wilson"
Article Synopsis
- * The study found specific differences in brain structure; particularly, the TSC + ASD group showed increased cortical thickness and curvature in language regions compared to others, but the typical asymmetry seen in TD, ASD, and TSC-ASD groups was absent.
- * While the initial results indicated that both ASD and TSC-related brain changes impact language-related regions, further research with larger groups is necessary to validate these findings, especially regarding tuber load
Inducible expression of neoantigens in mice would enable the study of endogenous antigen-specific naïve T cell responses in disease and infection, but has been difficult to generate because leaky antigen expression in the thymus results in central T cell tolerance. Here we develop inversion-induced joined neoantigen (NINJA), using RNA splicing, DNA recombination and three levels of regulation to prevent leakiness and allow tight control over neoantigen expression. We apply NINJA to create tumor cell lines with inducible neoantigen expression, which could be used to study antitumor immunity.
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