Association between Serum Folate and Vaginal High-Risk Human Papillomavirus Infections in United States Women.

Background: Serum concentration of folate was inversely associated with cervical intraepithelial neoplasia and cervical cancer in some studies. The association between folate and human papillomavirus (HPV) infection, a necessary cause of cervical cancer, has not been well elucidated.

Objectives: We evaluated whether serum folate concentrations were associated with high-risk HPV (hrHPV) infection.